Metabolic Regulation of Redox Status in Stem Cells
نویسندگان
چکیده
منابع مشابه
Redox Regulation in Cancer Stem Cells
CD44 was identified as a cell surface marker for cancer stem cells (CSCs) in various epithelial tumor. However, function-based evidence to support the role of CD44 in CSCs was not known. We found that expression of CD44, in particular variant forms of CD44 (CD44v), suppresses reactive oxygen species (ROS) levels by promoting the synthesis of reduced glutathione(GSH), a primary intracellular ant...
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Stem cells exert precise regulation to maintain a balance of self-renewal and differentiation programs to sustain tissue homeostasis throughout the life of an organism. Recent evidence suggests that this regulation is modulated, in part, via metabolic changes and modifications of nutrient-sensing pathways such as mTOR and AMPK. It is becoming increasingly clear that stem cells inhibit oxidative...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2014
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2014.6000